David J Schretlen Selected Research

Lesch-Nyhan Syndrome (Choreoathetosis Self Mutilation Hyperuricemia Syndrome)

1/2021	Deep brain stimulation in Lesch-Nyhan disease: outcomes from the patient's perspective.
1/2016	Do clinical features of Lesch-Nyhan disease correlate more closely with hypoxanthine or guanine recycling?
1/2015	Brain white matter volume abnormalities in Lesch-Nyhan disease and its variants.
1/2015	Clinical severity in Lesch-Nyhan disease: the role of residual enzyme and compensatory pathways.
12/2013	Regional brain volume abnormalities in Lesch-Nyhan disease and its variants: a cross-sectional study.
3/2011	Levodopa is not a useful treatment for Lesch-Nyhan disease.
1/2011	Mechanisms for phenotypic variation in Lesch-Nyhan disease and its variants.
3/2010	Attenuated variants of Lesch-Nyhan disease.
5/2006	Delineation of the motor disorder of Lesch-Nyhan disease.
5/2005	Lesch-Nyhan disease in a female with a clinically normal monozygotic twin.

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David J Schretlen Research Topics

Disease

10	Lesch-Nyhan Syndrome (Choreoathetosis Self Mutilation Hyperuricemia Syndrome) 01/2021 - 05/2005
7	Schizophrenia (Dementia Praecox) 01/2021 - 04/2009
5	Psychotic Disorders (Schizoaffective Disorder) 12/2021 - 11/2013
5	Cognitive Dysfunction 01/2016 - 01/2007
2	Dystonia (Limb Dystonia) 01/2016 - 03/2010
2	Neurodevelopmental Disorders 01/2016 - 01/2015
2	Delirium 10/2015 - 08/2013
1	Treatment-Resistant Schizophrenia 11/2021
1	Autistic Disorder (Autism) 01/2017
1	Dementia (Dementias) 12/2014
1	Huntington Disease (Huntington's Disease) 11/2013
1	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2013
1	Bipolar Disorder (Manic Depressive Psychosis) 06/2013
1	Pain (Aches) 01/2012
1	Glioma (Gliomas) 04/2009
1	Mental Disorders (Mental Disorder) 04/2009
1	Substance-Related Disorders (Drug Abuse) 01/2009
1	Brain Ischemia (Cerebral Ischemia) 12/2008
1	Intellectual Disability (Idiocy) 05/2006
1	Parkinson Disease (Parkinson's Disease) 09/2003

Drug/Important Bio-Agent (IBA)

7	Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)IBA 01/2016 - 05/2005
6	EnzymesIBA 01/2016 - 05/2005
5	purineIBA 01/2016 - 05/2005
5	Uric Acid (Urate)IBA 12/2014 - 05/2006
3	GuanineIBA 01/2016 - 05/2005
3	Biomarkers (Surrogate Marker)IBA 01/2015 - 11/2013
2	Polytetrafluoroethylene (Teflon)FDA Link 12/2021 - 01/2019
2	Glutamic Acid (Glutamate)FDA Link 01/2021 - 01/2018
2	Protons (Proton)IBA 01/2019 - 01/2018
2	HypoxanthineIBA 01/2016 - 05/2005
1	Glutathione (Reduced Glutathione)IBA 01/2021
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 12/2018
1	3- (1,4- diazabicyclo(3.2.2)nonan- 4- yl)- 6- fluorodibenzo(b,d)thiophene 5,5-dioxideIBA 12/2018
1	salicylhydroxamic acid (SHAM)IBA 01/2017
1	Biological ProductsIBA 01/2015
1	CytosineIBA 11/2013
1	Adenine FDA LinkGeneric 11/2013
1	acceleratory factor from growth hormone (AcG)IBA 11/2013
1	chemotactic factor inactivatorIBA 06/2013
1	Levodopa (L Dopa)FDA LinkGeneric 03/2011
1	AntibodiesIBA 05/2010
1	Leucine (L-Leucine)FDA Link 04/2009
1	AntioxidantsIBA 01/2007
1	TransferasesIBA 05/2005
1	Serotonin (5 Hydroxytryptamine)IBA 09/2003

Therapy/Procedure

3	Transcranial Direct Current Stimulation 11/2017 - 01/2012
2	Deep Brain Stimulation 11/2021 - 01/2021
2	General Anesthesia 10/2015 - 08/2013
1	Anesthesia 10/2015
1	Institutionalization (Institutionalized Persons) 08/2013
1	Therapeutics 01/2012
1	Activities of Daily Living (ADL) 01/2009